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A list of all the posts and pages found on the site. For you robots out there is an XML version available for digesting as well.

Posts

Future Blog Post

less than 1 minute read

Published: January 01, 2199

This post will show up by default. To disable scheduling of future posts, edit config.yml and set future: false.

Blog Post number 4

less than 1 minute read

Published: August 14, 2015

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 3

less than 1 minute read

Published: August 14, 2014

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 2

less than 1 minute read

Published: August 14, 2013

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 1

less than 1 minute read

Published: August 14, 2012

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

portfolio

From understanding to rational design of next-generation cancer therapies

This project aims to combine immunotherapy with classical cancer therapies at ultra-low, sublethal doses to maximize efficacy. Informed by single-cell analyses and advanced statistical inference methods, we employ mathematical modeling of intracellular damage dynamics to maximize treatment efficacy.

Dissecting and overcoming collective therapy resistance

This project studies how cancer cells collectively survive and resist treatment. We identify which cells resist chemotherapy using advanced data analysis methods and find new ways to target them. We simulate collective cancer cell behavior using a mechanistic model predicting effective treatment strategies. The ultimate goal is discovering new treatment combinations targeting cancer cell interactions and resistance.

publications

Syga, S., Nava-Sedeño, J. M., Brusch, L., & Deutsch, A. (2019). "A lattice-gas cellular automaton model for discrete excitable media." In Spirals and Vortices: In Culture, Nature, and Science (pp. 253-264). Springer.

Ilina, O., Gritsenko, P. G., Syga, S., et al. (2020). "Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion." Nature Cell Biology. 22(9), 1103-1115.

Barua, A.*, Syga, S.*, Mascheroni, P., Kavallaris, N., Meyer-Hermann, M., Deutsch, A., & Hatzikirou, H. (2020). "Entropy-driven cell decision-making predicts 'fluid-to-solid' transition in multicellular systems." New Journal of Physics. 22(12), 123034.

Scholich, A., Syga, S., Morales-Navarrete, H., et al. (2020). "Quantification of nematic cell polarity in three-dimensional tissues." PLOS Computational Biology. 16(12), e1008412.

Deutsch, A., Nava-Sedeño, J. M., Syga, S., & Hatzikirou, H. (2021). "BIO-LGCA: A cellular automaton modelling class for analysing collective cell migration." PLOS Computational Biology. 17(6), e1009066.

Syga, S., David-Rus, D., Schälte, Y., Hatzikirou, H., & Deutsch, A. (2021). "Inferring the effect of interventions on COVID-19 transmission networks." Scientific Reports. 11(1), 1-11.

Freitas, D., & Syga, S. (2022). "35 Cent weniger für Benzin und 17 Cent weniger für Diesel -- Der Tankrabatt ist angekommen." ifo Dresden berichtet. 29(5), 13-18.

Syga, S., Wolf-Gladrow, D., & Deutsch, A. (2022). "Mathematik der Pandemie." Springer Berlin.

Beunk, L., Wen, N., van Helvert, S., Bekker, B., Ran, L., Kang, R., Paulat, T., Syga, S., Deutsch, A., Friedl, P., & Wolf, K. (2023). "Cell jamming in a collagen-based interface assay: tuning by collagen density and proteolysis." Journal of Cell Science. 136, jcs260207.

Nava-Sedeño, J. M., Syga, S., & Deutsch, A. (2023). "Artificial patterns in spatially discrete models of cell migration and how to mitigate them." BIOMATH. 12(2), 2311177.

Syga, S., Jain, H. P., Krellner, M., Hatzikirou, H., & Deutsch, A. (2024). "Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy." PLOS Computational Biology. 20(8), e1012003.